Novel lycorine derivatives as anticancer agents: synthesis and in vitro biological evaluation.
نویسندگان
چکیده
Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.
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عنوان ژورنال:
- Molecules
دوره 19 2 شماره
صفحات -
تاریخ انتشار 2014